The anti-human Receptor tyrosine-protein kinase ErbB-3 monoclonal antibody from MyBioSource.com is a Mouse Monoclonal antibody to c-erbB-3, c-erbB3, ERBB3, and HER3. This antibody recognizes Human antigen. The anti-human Receptor tyrosine-protein kinase ErbB-3 monoclonal antibody has been validated for the following applications: Flow Cytometry, and Immunohistochemistry.
Description
Background: ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148- kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumours (2)